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Uma Maheswara Reddy, C.
- A Study of Adverse Drug Reactions Due to Antihypertensive Drugs in Diabetic Patients in a Multispecialty Hospital
Authors
1 Vinayaka Mission University, Sankari Main Road, Ariyanoor, Salem 636308, Tamil Nadu, IN
2 Sri. Ramachandra College of Pharmacy, Porur, Chennai 600116, Tamil Nadu, IN
Source
Journal of Pharmaceutical Research, Vol 11, No 2 (2012), Pagination: 44-48Abstract
Adverse drug reactions (ADRs) present a serious public health problem that can affect patients, caregivers, pharmaceutical companies, and the health care system as a whole. The objective of the present study was to evaluate Adverse Drug Reactions associated with antihypertensive drugs in diabetic patients. The present study was an open, non-comparative, observational study done to monitor ADRs associated with antihypertensive medications in diabetic patients in a multispeciality hospital. A total of 347 adverse drug reactions were observed in 740 diabetic hypertensive patients during 2008-2010. A high percentage of ADRs occurred in elderly and female patients. Of the 347 ADRs, 185 (53.3%) were mild, 122 (35.1%) were moderate and 40 (11.5%) were identified to be severe. Combination therapy was associated with significantly less occurrence of ADRs, with a total of 147 (42.3%) as compared to monotherapy (n=200, 57.6%). Among the various antihypertensive drugs used in diabetic patients, diuretics were associated with higher number of ADRs (37.1%), followed by ACE inhibitors (34.2%), beta blockers (18.1%) and calcium channel blockers (10.3%).Keywords
Adverse Drug Reaction, Hypertension, Diabetes, Angiotensin-Converting Enzyme Inhibitors, Beta-Blockers.- Stability Studies of a Polyherbal Formulation, Urito under Accelerated Conditions
Authors
1 St. Ann’s College of Pharmacy, Nayunipalli, Chirala - 523187, Prakasam District, Andhra Pradesh, IN
2 Vels University, Chennai, IN
3 Research and Development Center, Rumi Herbals Pvt. Ltd., Mugappair, Chennai, IN
4 Department of Pharmacognosy, Sri Ramachandra University, Porur, Chennai - 600 116, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 3 (2011), Pagination: 128-133Abstract
The stability studies of the polyherbal capsules of Urito, (recommended for urinary stones and urolithiasis) were performed under accelerated conditions of temperature and humidity in a stability chamber. The study was done for a period of 105 days under stable accelerated conditions and samples were taken on every 15th day for analysis. Various parameters like ash values, extractive values, total tannin content, mucilage content, loss on drying, weight variation and disintegration time were determined on 0, 15th, 30th, 45th, 60th, 75th, 90th and 105th days of the study period and were compared with the values of the already obtained (in-house) standard limits of the formulation. The results have shown that there was no significant difference in the values obtained when compared with the standard values except for very slight variations which were within the limits of the standard values. Thus it was concluded that the polyherbal capsules of Urito will be stable for a period of 2 years without losing intactness of its contents. This could be further confirmed by real time stability studies.
Keywords
Stability Studies, Stability Chamber, Accelerated Conditions, Polyherbal Capsules.- Hypoglycemic Activity of Erythrina varigata in Alloxan Induced Diabetic Mice
Authors
1 Maharaji College of Pharmacy, Chennai-600 090, IN
2 Sri Ramachandra College of Pharmacy, Chennai 600 116, IN